Journal article icon

Journal article

Mouse models of otitis media: strengths and limitations.

Abstract:

There has been a rapid rise in the use of the mouse to investigate pathobiology of otitis media. This is for good reason, including easy husbandry, but also capacity for genetic manipulation of the mouse. Insights into human disease have been gleaned from mouse models, but there are limitations of the mouse-to-man approach. First, important differences exist between mouse and man, particularly in immune function. Second, functional equivalence of genes in the 2 species is not ensured. Third, ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1177/0194599812449986

Authors


Bhutta, MF More by this author
Journal:
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
Volume:
147
Issue:
4
Pages:
611-614
Publication date:
2012-10-05
DOI:
EISSN:
1097-6817
ISSN:
0194-5998
URN:
uuid:675d9a8c-1b37-4ef9-bf8a-4a3926f29163
Source identifiers:
334783
Local pid:
pubs:334783
Language:
English
Keywords:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP