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Does galanin inhibit insulin secretion by opening of the ATP-regulated K+ channel in the beta-cell?

Abstract:

The intrapancreatic neuropeptide galanin potently inhibits glucose-induced insulin secretion. This effect is in part due to a repolarization of the beta-cells and ensuring reduction in the cytoplasmic free Ca2+ concentration, [Ca2+]i. We propos that galanin inhibition of beta-cell action potentials is associated with the appearance of ATP-regulated K+ channels. Galanin opens K+ channels in a patch membrane when applied to the external solution in the cell-attached patch configuration. However...

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Publication status:
Published

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Authors


Berggren, PO More by this author
Bokvist, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
Peptides
Volume:
10
Issue:
2
Pages:
453-457
Publication date:
1989
DOI:
EISSN:
1873-5169
ISSN:
0196-9781
URN:
uuid:675d7183-800a-4a29-9e29-e1dcc5b882c8
Source identifiers:
29461
Local pid:
pubs:29461

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