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Soluble urokinase plasminogen activator receptor as a prognostic marker in men participating in prostate cancer screening.

Abstract:

BACKGROUND: The urokinase plasminogen activator (uPA) system is involved in tissue remodelling processes and is up-regulated in many types of malignancies. We investigated whether serum levels of different forms of soluble uPA receptor (suPAR) are associated with survival and in particular with prostate cancer and cardiovascular disease mortality. METHODS: Using time-resolved fluorescence immunoassays, we measured intact suPAR [suPAR(I-III)] and intact plus cleaved suPAR [suPAR(I-III) + suPA...

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
Journal:
Journal of internal medicine More from this journal
Volume:
269
Issue:
3
Pages:
299-305
Publication date:
2011-03-01
DOI:
EISSN:
1365-2796
ISSN:
0954-6820
Language:
English
Keywords:
Pubs id:
pubs:365880
UUID:
uuid:67588f55-50a4-40d9-8ffa-efaeeafc89cf
Local pid:
pubs:365880
Source identifiers:
365880
Deposit date:
2013-11-16

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