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Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors

Abstract:

Yolk sac (YS) hematopoiesis is critical for the survival of the embryo and a major source of tissue-resident macrophages that persist into adulthood. Yet, the transcriptional and epigenetic regulation of YS hematopoiesis remains poorly characterized. Here we report that the epigenetic regulator Ezh2 is essential for YS hematopoiesis but dispensable for subsequent aorta–gonad–mesonephros (AGM) blood development. Loss of EZH2 activity in hemogenic endothelium (HE) leads to the generation of phe...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-021-27140-8

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Role:
Author
ORCID:
0000-0002-6827-3027
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Role:
Author
ORCID:
0000-0002-9333-2383
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Role:
Author
ORCID:
0000-0003-3841-6637
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Name:
RCUK | Medical Research Council
Publisher:
Springer Nature
Journal:
Nature Communications More from this journal
Volume:
12
Issue:
1
Article number:
7019
Publication date:
2021-12-02
Acceptance date:
2021-10-27
DOI:
EISSN:
2041-1723
Pmid:
34857757

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