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Journal article

The structure of OMCI, a novel lipocalin inhibitor of the complement system.

Abstract:

The complement (C) system is a potent innate immune defence system against parasites. We have recently characterised and expressed OmCI, a 16 kDa protein derived from the soft tick Ornithodoros moubata that specifically binds C5, thereby preventing C activation. The structure of recombinant OmCI determined at 1.9 A resolution confirms a lipocalin fold and reveals that the protein binds a fatty acid derivative that we have identified by mass spectrometry as ricinoleic acid. We propose that OmC...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2007.03.064

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Journal:
Journal of molecular biology
Volume:
369
Issue:
3
Pages:
784-793
Publication date:
2007-06-01
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
Source identifiers:
28040

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