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Isolating intrinsic noise sources in a stochastic genetic switch

Abstract:

The stochastic mutual repressor model is analysed using perturbation methods. This simple model of a gene circuit consists of two genes and three promotor states. Either of the two protein products can dimerize, forming a repressor molecule that binds to the promotor of the other gene. When the repressor is bound to a promotor, the corresponding gene is not transcribed and no protein is produced. Either one of the promotors can be repressed at any given time or both can be unrepressed, leavin...

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J. M. Newby More by this author
Publication date:
2011
URN:
uuid:674f4933-f486-42fe-8771-acbb7bd42a49
Local pid:
oai:eprints.maths.ox.ac.uk:1443

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