DXS106 and DXS559 flank the X-linked dystonia-parkinsonism syndrome locus (DYT3).

Journal article

The locus (DYT3) underlying the X-linked dystonia-parkinsonism syndrome (XDP) was delineated within proximal Xq12-Xq13.1 by analysis of linkage, allelic association, and haplotypes. Short tandem repeat polymorphisms at loci DXS227, DXS559, DXS453, DXS106, DXS339, and DXS135 were studied. The occurrence of a recombination within a three-generation family established DXS559 as the distal flanking marker of DYT3. /phi/ and /delta/ values were determined as indicators of the degree of allelic ass...

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Authors: Müller, U; Haberhausen, G; Wagner, T; Fairweather, N; Chelly, J

• Publication status: Published
• Journal: Genomics
• Volume: 23
• Issue: 1
• Pages: 114-117
• Publication date: 1994-09-01
• DOI: 10.1006/geno.1994.1465
• EISSN: 1089-8646
• ISSN: 0888-7543
• Language: English
• Keywords: Dystonia; Gene Frequency; X Chromosome; Alleles; Genetic Markers; Haplotypes; Humans; Philippines; Male; Parkinson Disease; Female; Chromosome Mapping