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Predictors of exacerbation risk and response to budesonide in patients with chronic obstructive pulmonary disease: a post-hoc analysis of three randomised trials

Abstract:

The peripheral blood eosinophil count might help identify those patients with chronic obstructive pulmonary disease (COPD) who will experience fewer exacerbations when taking inhaled corticosteroids (ICS). Previous post-hoc analyses have proposed eosinophil cutoffs that are both arbitrary and limited in evaluating complex interactions of treatment response. We modelled eosinophil count as a continuous variable to determine the characteristics that determine both exacerbation risk and clinical...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/s2213-2600(18)30006-7

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
Role:
Author
ORCID:
0000-0002-9993-2478
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Publisher:
Elsevier Publisher's website
Journal:
Lancet Respiratory Medicine Journal website
Volume:
6
Issue:
2
Pages:
117-126
Publication date:
2018-01-10
DOI:
EISSN:
2213-2619
ISSN:
2213-2600
Pubs id:
pubs:821447
URN:
uri:674863ec-59a1-4902-bdbc-87a0425784a5
UUID:
uuid:674863ec-59a1-4902-bdbc-87a0425784a5
Local pid:
pubs:821447
Paper number:
2
Language:
English

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