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A Flexible Approach for the Analysis of Rare Variants Allowing for a Mixture of Effects on Binary or Quantitative Traits

Abstract:

Multiple rare variants either within or across genes have been hypothesised to collectively influence complex human traits. The increasing availability of high throughput sequencing technologies offers the opportunity to study the effect of rare variants on these traits. However, appropriate and computationally efficient analytical methods are required to account for collections of rare variants that display a combination of protective, deleterious and null effects on the trait. We have devel...

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Authors


Clarke, GM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Journal:
PLoS Genetics
Volume:
9
Issue:
8
Publication date:
2013-08-05
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:67459f9d-4850-4162-8d56-499db70a81e0
Source identifiers:
432254
Local pid:
pubs:432254
Language:
English

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