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Journal article

A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype.

Abstract:

Three founder transgenic mice were generated with a 108 kb human genomic fragment containing the entire autosomal dominant polycystic kidney disease (ADPKD) gene, PKD1, plus the tuberous sclerosis gene, TSC2. Two lines were established (TPK1 and TPK3) each with approximately 30 copies of the transgene. Both lines produced full-length PKD1 mRNA and polycystin-1 protein that was developmentally regulated, similar to the endogenous pattern, with expression during renal embryogenesis and neonatal...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/9.18.2617

Authors


Pritchard, L More by this author
Sloane-Stanley, JA More by this author
Sharpe, JA More by this author
Aspinwall, R More by this author
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Journal:
Human molecular genetics
Volume:
9
Issue:
18
Pages:
2617-2627
Publication date:
2000-11-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:6743ef07-8ec8-4f69-a176-9d01b50f1f7e
Source identifiers:
202652
Local pid:
pubs:202652

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