Thesis icon

Thesis

Time-lapse super-resolution imaging reveals key principles for cis-limited Xist RNA localisation

Abstract:

Dosage compensation in XX female mammals is achieved by X chromosome inactivation (XCI). The key player in this process is the long noncoding RNA Xist (X inactive specific transcript), which associates in cis with the inactive X chromosome elect (Xi) to mediate gene silencing and heterochromatization. Xist spreads across the entire Xi, but little is known about the dynamics of this process, particularly in the context of single cells. This thesis documents the development of a new, time-re...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Division:
MSD
Department:
Biochemistry
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
ORCID:
0000-0002-1612-9699
Role:
Supervisor
Role:
Examiner
ORCID:
0000-0002-8726-7888
More from this funder
Name:
Medical Research Council
Funding agency for:
Rodermund, L
Grant:
MR/K501256/1
More from this funder
Name:
Vice-Chancellors’ Award
Funding agency for:
Rodermund, L
More from this funder
Name:
2019 Goodger and Schorstein Award
Funding agency for:
Rodermund, L
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP