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Journal article

FOXM1 regulates proliferation, senescence and oxidative stress in keratinocytes and cancer cells

Abstract:

Several transcription factors, including the master regulator of the epidermis, p63, are involved in controlling human keratinocyte proliferation and differentiation. Here, we report that in normal keratinocytes, the expression of FOXM1, a member of the Forkhead superfamily of transcription factors, is controlled by p63. We observe that, together with p63, FOXM1 strongly contributes to the maintenance of high proliferative potential in keratinocytes, whereas its expression decreases during di...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.18632/aging.100988

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Oxford Ludwig Institute
Department:
Unknown
Role:
Author
ORCID:
0000-0002-1575-8725
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Name:
Medical Research Council
Grant:
MC_U132670600
Publisher:
Impact Journals
Journal:
Aging More from this journal
Volume:
8
Issue:
7
Pages:
1384-1397
Publication date:
2016-07-03
Acceptance date:
2016-06-12
DOI:
EISSN:
1945-4589
Pmid:
27385468
Language:
English
Keywords:
Pubs id:
pubs:994545
UUID:
uuid:673d5803-ed74-4e7e-8896-ca8431000147
Local pid:
pubs:994545
Source identifiers:
994545
Deposit date:
2019-04-29

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