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Enhanced understanding of the host-pathogen interaction in sepsis: new opportunities for omic approaches.

Abstract:

Progress in sepsis research has been severely hampered by a heterogeneous disease phenotype, limiting the interpretation of clinical trials and the development of effective therapeutic interventions. Application of omics-based methodologies is advancing understanding of the dysregulated host immune response to infection in sepsis. However, the frequently elusive nature of the infecting organism in sepsis has limited efforts to understand the effect of disease heterogeneity involving the patho...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/S2213-2600(17)30045-0

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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Role:
Author
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
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Funding agency for:
Goh, C
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Funding agency for:
Knight, JC
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Publisher:
Elsevier Publisher's website
Journal:
Lancet Respiratory Medicine Journal website
Volume:
5
Issue:
3
Pages:
212-223
Publication date:
2017-02-05
Acceptance date:
2017-01-20
DOI:
EISSN:
2213-2619
ISSN:
2213-2600
Pubs id:
pubs:685253
URN:
uri:67332595-dee6-4626-88fc-3b6e13727f86
UUID:
uuid:67332595-dee6-4626-88fc-3b6e13727f86
Local pid:
pubs:685253
Language:
English
Keywords:

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