Journal article icon

Journal article

Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins.

Abstract:

We have applied a proteomics approach to analyze signaling cascades in human platelets stimulated by thrombin receptor activating peptide (TRAP). By analyzing basal and TRAP-activated platelets using 2-dimensional gel electrophoresis (2-DE), we detected 62 differentially regulated protein features. From these, 41 could be identified by liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS) and were found to derive from 31 different genes, 8 of which had not previously been reported...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1182/blood-2003-07-2392

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Pearce, A
Grant:
Wellcome Trust Prize Student
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Publisher:
American Society of Hematology
Journal:
Blood More from this journal
Volume:
103
Issue:
6
Pages:
2088-2095
Publication date:
2004-03-15
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Language:
English
Keywords:
Pubs id:
pubs:99937
UUID:
uuid:673095cf-f1d7-434f-81ac-544742a43b27
Local pid:
pubs:99937
Source identifiers:
99937
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP