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Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins.

Abstract:

We have applied a proteomics approach to analyze signaling cascades in human platelets stimulated by thrombin receptor activating peptide (TRAP). By analyzing basal and TRAP-activated platelets using 2-dimensional gel electrophoresis (2-DE), we detected 62 differentially regulated protein features. From these, 41 could be identified by liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS) and were found to derive from 31 different genes, 8 of which had not previously been reported...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1182/blood-2003-07-2392

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Biotechnology and Biological Sciences Research Council More from this funder
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Funding agency for:
Pearce, A
Grant:
Wellcome Trust Prize Student
Publisher:
American Society of Hematology Publisher's website
Journal:
Blood Journal website
Volume:
103
Issue:
6
Pages:
2088-2095
Publication date:
2004-03-15
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Source identifiers:
99937

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