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Clinical and functional characterization of CXCR1/CXCR2 biology in the relapse and radiotherapy resistance of primary PTEN-deficient prostate carcinoma

Abstract:

Functional impairment of the tumour suppressor PTEN is common in primary prostate cancer and has been linked to relapse post-radiotherapy (post-RT). Pre-clinical modelling supports elevated CXC chemokine signalling as a critical mediator of PTEN-depleted disease progression and therapeutic resistance. We assessed the correlation of PTEN deficiency with CXC chemokine signalling and its association with clinical outcomes. Gene expression analysis characterized a PTENLOW/CXCR1HIGH/CXCR2HIGH clus...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1093/narcan/zcaa012

Authors


Publisher:
Oxford University Press
Journal:
NAR Cancer More from this journal
Volume:
2
Issue:
3
Article number:
zcaa012
Publication date:
2020-07-03
Acceptance date:
2020-06-22
DOI:
ISSN:
2632-8674
Language:
English
Pubs id:
1117259
Local pid:
pubs:1117259
Deposit date:
2020-07-09

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