Journal article
Cannabinoid receptor 2 modulates neutrophil recruitment in a murine model of endotoxemia.
- Abstract:
-
The endocannabinoid system consists of endogenous lipid mediators and cannabinoid receptors (CB) 1 and 2. It has previously been demonstrated that activation of the leukocyte-expressed CB2 has anti-inflammatory effects in vivo. Here, we report its role under baseline conditions and in a model of low-dose endotoxemia by comparing CB2 knockout to littermate control mice. CB2-deficient mice displayed significantly more neutrophils and fewer monocytes in the bone marrow under steady state. In ini...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Edward P. Abraham Trust
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Novo Nordisk Foundation
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Bibliographic Details
- Publisher:
- Hindawi Publisher's website
- Journal:
- Mediators of Inflammation Journal website
- Volume:
- 2017
- Pages:
- 4315412
- Publication date:
- 2017-08-01
- Acceptance date:
- 2017-06-07
- DOI:
- EISSN:
-
1466-1861
- ISSN:
-
0962-9351
- Pmid:
-
28852269
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:724635
- UUID:
-
uuid:672a4241-0341-4131-b1cd-fee5ff7b325c
- Local pid:
- pubs:724635
- Deposit date:
- 2017-10-06
Terms of use
- Copyright holder:
- Greaves et al
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Theodore S. Kapellos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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