Thesis
Towards a structural understanding of the iRhom/ADAM17 complex
- Abstract:
-
The rhomboid-like superfamily consists of the active rhomboid proteases and the inactive rhomboid pseudoproteases. The latter group includes the iRhoms, a family of polytopic transmembrane proteins composed of a long N-terminal cytoplasmic domain followed by seven transmembrane helices (TMH), with a highly conserved loop between TMH1 and TMH2 called the iRhom Homology Domain (IRHD). There are two mammalian iRhoms; iRhom1, which is broadly expressed, and iRhom2, which is predominantly expre...
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Authors
Contributors
+ Lea, S
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Sub department:
Pathology Dunn School
Research group:
Lea Group
Oxford college:
Wadham College
Role:
Supervisor
ORCID:
0000-0001-9287-8053
+ Freeman, M
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Sub department:
Pathology Dunn School
Research group:
Freeman Group
Oxford college:
Lincoln College
Role:
Supervisor
ORCID:
0000-0003-0410-5451
Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Deposit date:
- 2021-03-30
Related Items
Terms of use
- Copyright holder:
- Shah, A
- Copyright date:
- 2020
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