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Temporal trends in prevalence of Plasmodium falciparum drug resistance alleles over two decades of changing antimalarial policy in coastal Kenya.

Abstract:

Molecular surveillance of drug resistance markers through time provides crucial information on genomic adaptations, especially in parasite populations exposed to changing drug pressures. To assess temporal trends of established genotypes associated with tolerance to clinically important antimalarials used in Kenya over the last two decades, we sequenced a region of the pfcrt locus encompassing codons 72-76 of the Plasmodium falciparum chloroquine resistance transporter, full-length pfmdr1 - e...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Publisher:
Elsevier
Journal:
International journal for parasitology. Drugs and drug resistance
Volume:
4
Issue:
3
Pages:
152-163
Publication date:
2014-12-01
DOI:
EISSN:
2211-3207
ISSN:
2211-3207
Source identifiers:
489177
Language:
English
Keywords:
Pubs id:
pubs:489177
UUID:
uuid:67277d78-caa1-4dfd-9255-4a71f5597bd1
Local pid:
pubs:489177
Deposit date:
2014-11-17

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