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Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes

Abstract:

The HMG-box transcription factor Sox2 plays a role throughout neurogenesis and also acts at other stages of development, as illustrated by the multiple organs affected in the anophthalmia syndrome caused by SOX2 mutations. Here we combined proteomic and genomic approaches to characterize gene regulation by Sox2 in neural stem cells. Chd7, a chromatin remodeling ATPase associated with CHARGE syndrome, was identified as a Sox2 transcriptional cofactor. Sox2 and Chd7 physically interact, have ov...

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Publisher copy:
10.1038/ng.825

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Journal:
Nature Genetics
Volume:
43
Issue:
6
Pages:
607-611
Publication date:
2011-06-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:6721094f-f571-4642-acc9-c11954ce8ea3
Source identifiers:
162113
Local pid:
pubs:162113
Language:
English

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