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Journal article

U.K. Controlled trial of intrapleural streptokinase for pleural infection.

Abstract:

BACKGROUND: Intrapleural fibrinolytic agents are used in the drainage of infected pleural-fluid collections. This use is based on small trials that did not have the statistical power to evaluate accurately important clinical outcomes, including safety. We conducted a trial to clarify the therapeutic role of intrapleural streptokinase. METHODS: In this double-blind trial, 454 patients with pleural infection (defined by the presence of purulent pleural fluid or pleural fluid with a pH below 7.2...

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Publication status:
Published

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Publisher copy:
10.1056/nejmoa042473

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Journal:
New England journal of medicine
Volume:
352
Issue:
9
Pages:
865-874
Publication date:
2005-03-01
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
Source identifiers:
10736

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