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U.K. Controlled trial of intrapleural streptokinase for pleural infection.

Abstract:

BACKGROUND: Intrapleural fibrinolytic agents are used in the drainage of infected pleural-fluid collections. This use is based on small trials that did not have the statistical power to evaluate accurately important clinical outcomes, including safety. We conducted a trial to clarify the therapeutic role of intrapleural streptokinase. METHODS: In this double-blind trial, 454 patients with pleural infection (defined by the presence of purulent pleural fluid or pleural fluid with a pH below 7.2...

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Publication status:
Published

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Publisher copy:
10.1056/nejmoa042473

Authors


Maskell, NA More by this author
Davies, CW More by this author
Hedley, EL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, Biomedical Research Centre, Experimental Medicine Division
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Journal:
The New England journal of medicine
Volume:
352
Issue:
9
Pages:
865-874
Publication date:
2005-03-05
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
URN:
uuid:671b4151-08f4-49e1-a1ea-3f0bdf79300c
Source identifiers:
10736
Local pid:
pubs:10736

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