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No genetic overlap between circulating iron levels and Alzheimer's disease

Abstract:

Iron deposition in the brain is a prominent feature of Alzheimer's disease (AD). Recently, peripheral iron measures have also been shown to be associated with AD status. However, it is not known whether these associations are causal: do elevated or depleted iron levels throughout life have an effect on AD risk? We evaluate the effects of peripheral iron on AD risk using a genetic profile score approach by testing whether variants affecting iron, transferrin, or ferritin levels selected from G...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3233/JAD-170027

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Publisher:
IOS Press Publisher's website
Journal:
Journal of Alzheimer's Diseases Journal website
Volume:
59
Issue:
1
Pages:
85-99
Publication date:
2017-07-03
Acceptance date:
2017-04-20
DOI:
EISSN:
1875-8908
ISSN:
1387-2877
Source identifiers:
700440
Language:
English
Keywords:
Pubs id:
pubs:700440
UUID:
uuid:671aae93-8727-4701-bb74-d83f8f8fe771
Local pid:
pubs:700440
Deposit date:
2017-08-01

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