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The role of Polo-like kinase 1 in the inhibition of centrosome separation after ionizing radiation.

Abstract:

Activation of the G2/M cell cycle checkpoint by DNA damage prevents cells from entering mitosis. Centrosome separation is initiated in G2 phase and completed in M phase. This critical process for cell division is targeted by G2/M checkpoint. Here we show that Plk1 signaling plays an important role in regulation of centrosome separation after DNA damage. Constitutively active Plk1 overrides the inhibition of centrosome separation induced by DNA damage. This inhibition is dependent on ATM, but ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m505450200

Authors


Fletcher, L More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
The Journal of biological chemistry
Volume:
280
Issue:
52
Pages:
42994-42999
Publication date:
2005-12-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:6719afe1-8f1e-4164-abb3-25aafb14d15f
Source identifiers:
131370
Local pid:
pubs:131370

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