Journal article
The role of Polo-like kinase 1 in the inhibition of centrosome separation after ionizing radiation.
- Abstract:
-
Activation of the G2/M cell cycle checkpoint by DNA damage prevents cells from entering mitosis. Centrosome separation is initiated in G2 phase and completed in M phase. This critical process for cell division is targeted by G2/M checkpoint. Here we show that Plk1 signaling plays an important role in regulation of centrosome separation after DNA damage. Constitutively active Plk1 overrides the inhibition of centrosome separation induced by DNA damage. This inhibition is dependent on ATM, but ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1074/jbc.m505450200
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Authors
Bibliographic Details
- Journal:
- The Journal of biological chemistry
- Volume:
- 280
- Issue:
- 52
- Pages:
- 42994-42999
- Publication date:
- 2005-12-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:6719afe1-8f1e-4164-abb3-25aafb14d15f
- Source identifiers:
-
131370
- Local pid:
- pubs:131370
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2005
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