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The effects of tertiary and quaternary infections on the epidemiology of dengue.

Abstract:

The epidemiology of dengue is characterised by irregular epidemic outbreaks and desynchronised dynamics of its four co-circulating virus serotypes. Whilst infection by one serotype appears to convey life-long protection to homologous infection, it is believed to be a risk factor for severe disease manifestations upon secondary, heterologous infection due to the phenomenon of Antibody-Dependent Enhancement (ADE). Subsequent clinical infections are rarely reported and, since the majority of den...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0012347

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Institution:
University of Oxford
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
More from this funder
Funding agency for:
Recker, M
Biotechnology and Biological Sciences Research Council More from this funder
Royal Society More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
5
Issue:
8
Pages:
e12347
Publication date:
2010
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:6715048a-588b-48f1-9649-e1c81ed4c2e5
Source identifiers:
98256
Local pid:
pubs:98256

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