- Abstract:
-
Containment of hepatitis C virus (HCV) and other chronic human viral infections is associated with persistence of virus-specific CD4 T cells, but ex vivo characterization of circulating CD4 T cells has not been achieved. To further define the phenotype and function of these cells, we developed a novel approach for the generation of tetrameric forms of MHC class II/peptide complexes that is based on the cellular peptide-exchange mechanism. HLA-DR molecules were expressed as precursors with a c...
Expand abstract - Publisher copy:
- 10.1172/jci200318509
-
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- Journal:
- The Journal of clinical investigation
- Volume:
- 112
- Issue:
- 6
- Pages:
- 831-842
- Publication date:
- 2003-09-05
- DOI:
- EISSN:
-
1558-8238
- ISSN:
-
0021-9738
- URN:
-
uuid:670e84d5-bba0-4ec8-8089-65b7ec6c07dc
- Source identifiers:
-
13346
- Local pid:
- pubs:13346
- Copyright date:
- 2003
Journal article
Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers.
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