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Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers.

Abstract:

Containment of hepatitis C virus (HCV) and other chronic human viral infections is associated with persistence of virus-specific CD4 T cells, but ex vivo characterization of circulating CD4 T cells has not been achieved. To further define the phenotype and function of these cells, we developed a novel approach for the generation of tetrameric forms of MHC class II/peptide complexes that is based on the cellular peptide-exchange mechanism. HLA-DR molecules were expressed as precursors with a c...

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Publisher copy:
10.1172/jci200318509

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Journal:
The Journal of clinical investigation
Volume:
112
Issue:
6
Pages:
831-842
Publication date:
2003-09-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:670e84d5-bba0-4ec8-8089-65b7ec6c07dc
Source identifiers:
13346
Local pid:
pubs:13346

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