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Cell entry mechanism of enzymatic bacterial colicins: porin recruitment and the thermodynamics of receptor binding.

Abstract:

Binding of enzymatic E colicins to the vitamin B12 receptor, BtuB, is the first stage in a cascade of events that culminate in the translocation of the cytotoxic nuclease into the Escherichia coli cytoplasm and release of its tightly bound immunity protein. A dogma of colicin biology is that the toxin coiled-coil connecting its functional domains must unfold or unfurl to span the periplasm, with recent reports claiming this reaction is initiated by receptor binding. We report isothermal titra...

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Publisher copy:
10.1073/pnas.0503567102

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
102
Issue:
39
Pages:
13849-13854
Publication date:
2005-09-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:670c3186-8096-4f77-a546-af9d91bcc9a9
Source identifiers:
310193
Local pid:
pubs:310193

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