Journal article icon

Journal article

The effects of tumor necrosis factor (TNF) derivatives on TNF receptors.

Abstract:

The pleiotropic cytokine TNF has been implicated in the regulation of many immune and inflammatory responses in vivo, and in addition exerts a wide range of effects on target cells in vitro. However, although two cell surface receptors for TNF have been identified, and their cDNAs cloned, the amino acid residues necessary for the biological activity of TNF have not been characterized. We have therefore constructed derivatives of TNF termed 'muteins', in which the first 3 to 7 amino acids of n...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Tchorzewski, H More by this author
Paleolog, E More by this author
Brennan, F More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Expand authors...
Journal:
Cytokine
Volume:
5
Issue:
2
Pages:
125-132
Publication date:
1993-03-05
DOI:
EISSN:
1096-0023
ISSN:
1043-4666
URN:
uuid:670958e3-1a98-4926-8365-c1ffcabbc1cc
Source identifiers:
481809
Local pid:
pubs:481809

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP