Journal article icon

Journal article

Critical role for IL-4 in the development of transplant arteriosclerosis in the absence of CD40-CD154 costimulation.

Abstract:

Blockade of the CD40-CD154 pathway can inhibit CD4(+) T cell activation but is unable to prevent immune responses mediated by CD8(+) T cells. However, even in the absence of CD8(+) T cells, inhibition of the CD40-CD154 pathway is insufficient to prevent the development of transplant arteriosclerosis. This study investigated the mechanisms of transplant arteriosclerosis in the absence of the CD40 pathway. C57BL/6 CD40(-/-) (H2(b)) recipients were transplanted with MHC-mismatched BALB/c (H2(d))...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.4049/jimmunol.167.1.532

Authors


Ensminger, SM More by this author
Spriewald, BM More by this author
Sorensen, HV More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Expand authors...
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
167
Issue:
1
Pages:
532-541
Publication date:
2001-07-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:67040bb8-ddc9-4516-b95d-6a3802aad2e6
Source identifiers:
117832
Local pid:
pubs:117832

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP