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What is the mechanism of action of anti-tumour necrosis factor-alpha antibody in rheumatoid arthritis?

Abstract:

The rationale for anti-tumour necrosis factor-alpha (anti-TNFalpha) therapy in rheumatoid arthritis (RA) is based on experiments on cultures of human rheumatoidjoint tissue, supported by experiments in animal models, all of which demonstrated that anti-TNFalpha antibody had profound effects on the disease activity. Clinical trials have substantiated this concept, and we have used the serum samples from the clinical trials, as well as biopsies to study the changes occurring during anti-TNFalph...

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Publication status:
Published

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Publisher copy:
10.1159/000237393

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
International archives of allergy and immunology
Volume:
111
Issue:
4
Pages:
362-365
Publication date:
1996-12-05
DOI:
EISSN:
1423-0097
ISSN:
1018-2438
URN:
uuid:66fae182-1ebf-452a-9dbf-3659764d3e24
Source identifiers:
481618
Local pid:
pubs:481618

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