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Optimism bias leads to inconclusive results-an empirical study.

Abstract:

OBJECTIVE: Optimism bias refers to unwarranted belief in the efficacy of new therapies. We assessed the impact of optimism bias on a proportion of trials that did not answer their research question successfully and explored whether poor accrual or optimism bias is responsible for inconclusive results. STUDY DESIGN: Systematic review. SETTING: Retrospective analysis of a consecutive-series phase III randomized controlled trials (RCTs) performed under the aegis of National Cancer Institute Coop...

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Publication status:
Published

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Journal:
Journal of clinical epidemiology More from this journal
Volume:
64
Issue:
6
Pages:
583-593
Publication date:
2011-06-01
DOI:
EISSN:
1878-5921
ISSN:
0895-4356
Language:
English
Keywords:
Pubs id:
pubs:107201
UUID:
uuid:66fa54ee-5df2-4c27-832f-1bc3c74428a9
Local pid:
pubs:107201
Source identifiers:
107201
Deposit date:
2012-12-19

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