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Journal article

PPAR-alpha activation required for decreased glucose uptake and increased susceptibility to injury during ischemia.

Abstract:

The transcription of key metabolic regulatory enzymes in the heart is altered in the diabetic state, yet little is known of the underlying mechanisms. The aim of this study was to investigate the role of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) in modulating cardiac insulin-sensitive glucose transporter (GLUT-4) protein levels in altered metabolic states and to determine the functional consequences by assessing cardiac ischemic tolerance. Wild-type and PPAR-alpha-null mou...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.00200.2004

Authors


Panagia, M More by this author
Gibbons, GF More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
288
Issue:
6
Pages:
H2677-H2683
Publication date:
2005-06-05
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
URN:
uuid:66f2991a-e96d-482f-bfaf-f4b290a4a223
Source identifiers:
106161
Local pid:
pubs:106161

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