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Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype.

Abstract:

OBJECTIVES: To investigate the genotypic and phenotypic effects of in vitro resistance selection with lamivudine and/or the second generation non-nucleoside reverse transcriptase inhibitor (NNRTI) quinoxaline HBY097 using HIV-1 isolates carrying the multi-nucleoside resistance pattern linked to the Q151M mutation. METHODS: Virus strains were selected in C8166 cells in the presence of increasing concentrations of lamivudine or HBY097. In parallel control experiments, the virus was cultured in ...

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Publication status:
Published

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Journal:
AIDS (London, England)
Volume:
15
Issue:
5
Pages:
553-561
Publication date:
2001-03-05
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
URN:
uuid:66e4b9ff-17e8-40bd-a199-e569ccb74949
Source identifiers:
26156
Local pid:
pubs:26156

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