Journal article icon

Journal article

A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis

Abstract:

Limited clinical benefits derived from anti-VEGF therapy have driven the identification of new targets involved in tumor angiogenesis. Here, we report an integrative meta-analysis to define the transcriptional program underlying angiogenesis in human cancer. This approach identified ELTD1, an orphan G-protein-coupled receptor whose expression is induced by VEGF/bFGF and repressed by DLL4 signaling. Extensive analysis of multiple cancer types demonstrates significant upregulation of ELTD1 in t...

Expand abstract

Actions


Access Document


Publisher copy:
10.1016/j.ccr.2013.06.004

Authors


Masiero, M More by this author
Simões, F More by this author
Peterkin, T More by this author
Expand authors...
Journal:
Cancer Cell
Volume:
24
Issue:
2
Pages:
229-241
Publication date:
2013-08-12
DOI:
EISSN:
1878-3686
ISSN:
1535-6108
URN:
uuid:66dede5f-e387-4d1d-a69d-632aa4b3bdeb
Source identifiers:
418883
Local pid:
pubs:418883
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP