- Abstract:
-
Limited clinical benefits derived from anti-VEGF therapy have driven the identification of new targets involved in tumor angiogenesis. Here, we report an integrative meta-analysis to define the transcriptional program underlying angiogenesis in human cancer. This approach identified ELTD1, an orphan G-protein-coupled receptor whose expression is induced by VEGF/bFGF and repressed by DLL4 signaling. Extensive analysis of multiple cancer types demonstrates significant upregulation of ELTD1 in t...
Expand abstract - Publisher copy:
- 10.1016/j.ccr.2013.06.004
-
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- Journal:
- Cancer Cell
- Volume:
- 24
- Issue:
- 2
- Pages:
- 229-241
- Publication date:
- 2013-08-12
- DOI:
- EISSN:
-
1878-3686
- ISSN:
-
1535-6108
- URN:
-
uuid:66dede5f-e387-4d1d-a69d-632aa4b3bdeb
- Source identifiers:
-
418883
- Local pid:
- pubs:418883
- Language:
- English
- Copyright date:
- 2013
Journal article
A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis
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