Journal article icon

Journal article

Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury

Abstract:

Neuropathic pain following peripheral nerve injury is associated with hyperexcitability in damaged myelinated sensory axons, which begins to normalise over time. We investigated the composition and distribution of shaker-type-potassium channels (Kv1 channels) within the nodal complex of myelinated axons following injury. At the neuroma that forms after damage, expression of Kv1.1 and 1.2 (normally localised to the juxtaparanode) was markedly decreased. In contrast Kv1.4 and 1.6, which were ha...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.7554/eLife.12661

Authors


More by this author
Department:
Oxford, MSD, Clinical Neurosciences
Role:
Author
Expand authors...
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
5
Pages:
Article e12661
Publication date:
2016-04-01
Acceptance date:
2016-03-15
DOI:
ISSN:
2050-084X
Pubs id:
pubs:612952
URN:
uri:66d8d579-20b2-4937-b752-cf4a3f2d7a57
UUID:
uuid:66d8d579-20b2-4937-b752-cf4a3f2d7a57
Local pid:
pubs:612952

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP