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Multiple regions within 8q24 independently affect risk for prostate cancer.

Abstract:

After the recent discovery that common genetic variation in 8q24 influences inherited risk of prostate cancer, we genotyped 2,973 SNPs in up to 7,518 men with and without prostate cancer from five populations. We identified seven risk variants, five of them previously undescribed, spanning 430 kb and each independently predicting risk for prostate cancer (P = 7.9 x 10(-19) for the strongest association, and P < 1.5 x 10(-4) for five of the variants, after controlling for each of the others...

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Publication status:
Published

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Publisher copy:
10.1038/ng2015

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Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics, Clinical Medicine
Role:
Author
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Journal:
Nature genetics
Volume:
39
Issue:
5
Pages:
638-644
Publication date:
2007-05-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:66d4ef5f-d0f6-40a5-923c-3670cda716ff
Source identifiers:
103464
Local pid:
pubs:103464

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