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Neutrophil antimicrobial proteins enhance Shigella flexneri adhesion and invasion.

Abstract:

Shigella flexneri is an enteric pathogen that causes massive inflammation and destruction of the human intestinal epithelium. Neutrophils are the first cells of the innate immune system recruited to the site of infection. These cells can attack microbes by phagocytosis, Neutrophil Extracellular Trap (NET) formation and degranulation. Here, we investigated how neutrophil degranulation affects virulence and show that exposure of Shigella to granular proteins enhances infection of epithelial cel...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Journal:
Cellular microbiology
Volume:
12
Issue:
8
Pages:
1134-1143
Publication date:
2010-08-01
DOI:
EISSN:
1462-5822
ISSN:
1462-5814
Source identifiers:
249469
Language:
English
Keywords:
Pubs id:
pubs:249469
UUID:
uuid:66d4d0f3-b402-4d8d-85d5-a38b3fc9cacd
Local pid:
pubs:249469
Deposit date:
2012-12-19

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