Neutrophil antimicrobial proteins enhance Shigella flexneri adhesion and invasion.

Journal article

Shigella flexneri is an enteric pathogen that causes massive inflammation and destruction of the human intestinal epithelium. Neutrophils are the first cells of the innate immune system recruited to the site of infection. These cells can attack microbes by phagocytosis, Neutrophil Extracellular Trap (NET) formation and degranulation. Here, we investigated how neutrophil degranulation affects virulence and show that exposure of Shigella to granular proteins enhances infection of epithelial cel...

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Authors: Eilers, B; Mayer-Scholl, A; Walker, T; Tang, C; Weinrauch, Y

• Journal: Cellular microbiology
• Volume: 12
• Issue: 8
• Pages: 1134-1143
• Publication date: 2010-08-01
• DOI: 10.1111/j.1462-5822.2010.01459.x
• EISSN: 1462-5822
• ISSN: 1462-5814
• Language: English
• Keywords: Hela Cells; Neutrophils; Immune Evasion; Antimicrobial Cationic Peptides; Microbial Viability; Epithelial Cells; Bacterial Adhesion; Humans; Shigella flexneri; Colony Count, Microbial