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Gain-of-function mutation of tristetraprolin impairs negative feedback control of macrophages in vitro yet has overwhelmingly anti-inflammatory consequences in vivo

Abstract:

The mRNA-destabilizing factor tristetraprolin (TTP) binds in a sequence-specific manner to the 3' untranslated regions of many proinflammatory mRNAs and recruits complexes of nucleases to promote rapid mRNA turnover. Mice lacking TTP develop a severe, spontaneous inflammatory syndrome characterized by the overexpression of tumor necrosis factor and other inflammatory mediators. However, TTP also employs the same mechanism to inhibit the expression of the potent anti-inflammatory cytokine inte...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/mcb.00536-16

Authors


O'Neil, JD More by this author
Ridley, ML More by this author
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Publisher:
American Society for Microbiology Publisher's website
Journal:
Molecular and Cellular Biology Journal website
Volume:
37
Issue:
11
Pages:
e00536-16
Publication date:
2017-03-06
Acceptance date:
2017-02-25
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
Pubs id:
pubs:694509
URN:
uri:66cd83d2-e49f-4e2d-b7f3-7425e65d84f4
UUID:
uuid:66cd83d2-e49f-4e2d-b7f3-7425e65d84f4
Local pid:
pubs:694509

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