Journal article
Gain-of-function mutation of tristetraprolin impairs negative feedback control of macrophages in vitro yet has overwhelmingly anti-inflammatory consequences in vivo
- Abstract:
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The mRNA-destabilizing factor tristetraprolin (TTP) binds in a sequence-specific manner to the 3' untranslated regions of many proinflammatory mRNAs and recruits complexes of nucleases to promote rapid mRNA turnover. Mice lacking TTP develop a severe, spontaneous inflammatory syndrome characterized by the overexpression of tumor necrosis factor and other inflammatory mediators. However, TTP also employs the same mechanism to inhibit the expression of the potent anti-inflammatory cytokine inte...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
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- Files:
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(pdf, 1.7MB)
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- Publisher copy:
- 10.1128/mcb.00536-16
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Authors
Funding
Bibliographic Details
- Publisher:
- American Society for Microbiology Publisher's website
- Journal:
- Molecular and Cellular Biology Journal website
- Volume:
- 37
- Issue:
- 11
- Pages:
- e00536-16
- Publication date:
- 2017-03-06
- Acceptance date:
- 2017-02-25
- DOI:
- EISSN:
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1098-5549
- ISSN:
-
0270-7306
- Pubs id:
-
pubs:694509
- URN:
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uri:66cd83d2-e49f-4e2d-b7f3-7425e65d84f4
- UUID:
-
uuid:66cd83d2-e49f-4e2d-b7f3-7425e65d84f4
- Local pid:
- pubs:694509
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright holder:
- O'Neil et al
- Copyright date:
- 2017
- Notes:
- © 2017 O'Neil et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
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