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Increased activation of the hypoxia-inducible factor pathway in varicose veins

Abstract:

Background: Venous hypoxia has been postulated to contribute to varicose vein (VV) formation. Direct measurements of vein wall oxygen tension have previously demonstrated that the average minimum oxygen tensions were significantly lower in VVs compared with non-varicose veins (NVVs). Hypoxia-inducible factors (HIFs) are nuclear transcriptional factors that regulate the expression of several genes of oxygen homeostasis. This study aimed to investigate if hypoxia was associated with VVs by asse...

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Publisher copy:
10.1016/j.jvs.2011.10.111

Authors


Kiriakidis, S More by this author
Paleolog, EM More by this author
Davies, AH More by this author
Journal:
Journal of Vascular Surgery
Volume:
55
Issue:
5
Publication date:
2012-05-05
DOI:
EISSN:
1097-6809
ISSN:
0741-5214
URN:
uuid:66be0754-e004-49e0-8d08-5efb0931d138
Source identifiers:
329914
Local pid:
pubs:329914
Language:
English

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