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Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia.

Abstract:

Tibetan natives have lived on the Tibetan plateau (altitude ∼ 4,000 m) for at least 25,000 years, and as such they are adapted to life and reproduction in a hypoxic environment. Recent studies have identified two genetic loci, EGLN1 and EPAS1, that have undergone natural selection in Tibetans, and further demonstrated an association of EGLN1/EPAS1 genotype with hemoglobin concentration. Both genes encode major components of the hypoxia-inducible factor (HIF) transcriptional pathway, which coo...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Publisher:
American Physiological Society
Journal:
Journal of applied physiology (Bethesda, Md. : 1985)
Volume:
116
Issue:
7
Pages:
893-904
Publication date:
2014-04-05
DOI:
EISSN:
1522-1601
ISSN:
8750-7587
URN:
uuid:66bbaff3-24cd-4135-ab8e-23ebc2f8470e
Source identifiers:
429245
Local pid:
pubs:429245

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