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Ultrasound-mediated cavitation-enhanced extravasation of mesoporous silica nanoparticles for controlled-release drug delivery

Abstract:

Mesoporous silica nanoparticles have been reported as suitable drug carriers, but their successful delivery to target tissues following systemic administration remains a challenge. In the present work, ultrasound-induced inertial cavitation was evaluated as a mechanism to promote their extravasation in a flow-through tissue-mimicking agarose phantom. Two different ultrasound frequencies, 0.5 or 1.6 MHz, with pressures in the range 0.5–4 MPa were used to drive cavitation activity which was det...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.cej.2017.12.051

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Oxford college:
St Cross College
Role:
Author
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Grant:
Advanced Grant VERDI (ERC-2015 AdG proposal no. 694160)
Publisher:
Elsevier Publisher's website
Journal:
Chemical Engineering Journal Journal website
Volume:
340
Pages:
2-8
Publication date:
2017-12-12
Acceptance date:
2017-12-01
DOI:
ISSN:
1385-8947
Pubs id:
pubs:830163
URN:
uri:66b6cfa3-fb95-4069-882f-5d53bc98be97
UUID:
uuid:66b6cfa3-fb95-4069-882f-5d53bc98be97
Local pid:
pubs:830163

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