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Protocadherin 11X/Y a human-specific gene pair: an immunohistochemical survey of fetal and adult brains.

Abstract:

Protocadherins 11X and 11Y are cell adhesion molecules of the δ1-protocadherin family. Pcdh11X is present throughout the mammalian radiation; however, 6 million years ago (MYA), a reduplicative translocation of the Xq21.3 block onto what is now human Yp11 created the Homo sapiens-specific PCDH11Y. Therefore, modern human females express PCDH11X whereas males express both PCDH11X and PCDH11Y. PCDH11X/Y has been subject to accelerated evolution resulting in human-specific changes to both protei...

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Publisher copy:
10.1093/cercor/bhs181

Authors


Journal:
Cerebral cortex (New York, N.Y. : 1991)
Volume:
23
Issue:
8
Pages:
1933-1941
Publication date:
2013-08-05
DOI:
EISSN:
1460-2199
ISSN:
1047-3211
URN:
uuid:66ab8fd5-a918-4547-aaa8-d67542849be3
Source identifiers:
470818
Local pid:
pubs:470818

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