- Abstract:
-
Protocadherins 11X and 11Y are cell adhesion molecules of the δ1-protocadherin family. Pcdh11X is present throughout the mammalian radiation; however, 6 million years ago (MYA), a reduplicative translocation of the Xq21.3 block onto what is now human Yp11 created the Homo sapiens-specific PCDH11Y. Therefore, modern human females express PCDH11X whereas males express both PCDH11X and PCDH11Y. PCDH11X/Y has been subject to accelerated evolution resulting in human-specific changes to both protei...
Expand abstract - Publisher copy:
- 10.1093/cercor/bhs181
-
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- Journal:
- Cerebral cortex (New York, N.Y. : 1991)
- Volume:
- 23
- Issue:
- 8
- Pages:
- 1933-1941
- Publication date:
- 2013-08-05
- DOI:
- EISSN:
-
1460-2199
- ISSN:
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1047-3211
- URN:
-
uuid:66ab8fd5-a918-4547-aaa8-d67542849be3
- Source identifiers:
-
470818
- Local pid:
- pubs:470818
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Protocadherin 11X/Y a human-specific gene pair: an immunohistochemical survey of fetal and adult brains.
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