Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants.

Journal article

Acquired protection from Plasmodium falciparum placental malaria, a major cause of maternal, fetal, and infant morbidity, is mediated by IgG specific for the P. falciparum erythrocyte membrane protein 1 variant VAR2CSA. This protein enables adhesion of P. falciparum-infected erythrocytes to chondroitin sulfate A in the intervillous space. Although interclonal variation of the var2csa gene is lower than that among var genes in general, VAR2CSA-specific Abs appear to target mainly polymorphic e...

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Authors: Barfod, L; Dobrilovic, T; Magistrado, P; Khunrae, P; Viwami, F

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 185
• Issue: 12
• Pages: 7553-7561
• Publication date: 2010-12-01
• DOI: 10.4049/jimmunol.1002390
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Malaria Vaccines; Erythrocytes; Child; Pregnancy; Antibodies, Monoclonal; Humans; Protozoan Proteins; Plasmodium falciparum; Male; Pregnancy Complications, Infectious; Placenta; Antibodies, Protozoan; Malaria, Falciparum; Chondroitin Sulfates; Child, Preschool; Adult; B-Lymphocytes; Epitopes; Female