Journal article icon

Journal article

CRISPR-Cas gene perturbation and editing in human induced pluripotent stem cells

Abstract:

Directing the fates of human pluripotent stem cells (hPSC) to generate a multitude of differentiated cell types allows the study of the genetic regulation of human development and disease. The translational potential of hPSC is maximized by exploiting CRISPR to silence or activate genes with spatial and temporal precision permanently or reversibly. Here, we summarize the increasingly refined and diverse CRISPR toolkit for the latter forms of gene perturbation in hPSC and their downstream appl...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1089/crispr.2021.0063

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More from this funder
Grant:
IS-BRC-1215-20008
Publisher:
Mary Ann Liebert Publisher's website
Journal:
CRISPR Journal Journal website
Publication date:
2021-09-28
Acceptance date:
2021-08-22
DOI:
EISSN:
2573-1602
ISSN:
2573-1599
Pmid:
34582693
Language:
English
Keywords:
Pubs id:
1197912
Local pid:
pubs:1197912
Deposit date:
2021-10-10

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP