Journal article
CRISPR-Cas gene perturbation and editing in human induced pluripotent stem cells
- Abstract:
-
Directing the fates of human pluripotent stem cells (hPSC) to generate a multitude of differentiated cell types allows the study of the genetic regulation of human development and disease. The translational potential of hPSC is maximized by exploiting CRISPR to silence or activate genes with spatial and temporal precision permanently or reversibly. Here, we summarize the increasingly refined and diverse CRISPR toolkit for the latter forms of gene perturbation in hPSC and their downstream appl...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1089/crispr.2021.0063
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Authors
Funding
Bibliographic Details
- Publisher:
- Mary Ann Liebert Publisher's website
- Journal:
- CRISPR Journal Journal website
- Publication date:
- 2021-09-28
- Acceptance date:
- 2021-08-22
- DOI:
- EISSN:
-
2573-1602
- ISSN:
-
2573-1599
- Pmid:
-
34582693
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1197912
- Local pid:
- pubs:1197912
- Deposit date:
- 2021-10-10
Terms of use
- Copyright holder:
- Mary Ann Liebert, Inc., publishers
- Copyright date:
- 2021
- Rights statement:
- Copyright 2021, Mary Ann Liebert, Inc., publishers.
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