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Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations.

Abstract:

BACKGROUND: Severe malaria is characterized by microvascular obstruction, endothelial dysfunction, and reduced levels of L-arginine and nitric oxide (NO). L-Arginine infusion improves endothelial function in moderately severe malaria. Neither the longitudinal course of endothelial dysfunction nor factors associated with recovery have been characterized in severe malaria. METHODS: Endothelial function was measured longitudinally in adults with severe malaria (n = 49) or moderately severe malar...

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Publication status:
Published

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Publisher copy:
10.1086/590209

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Journal:
The Journal of infectious diseases
Volume:
198
Issue:
4
Pages:
602-608
Publication date:
2008-08-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:6688329a-9ba2-4ddc-83cf-5422e1d38020
Source identifiers:
61499
Local pid:
pubs:61499

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