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Investigating the role of Rts1 in DNA replication initiation

Abstract:
Background: Understanding DNA replication initiation is essential to understand the mis-regulation of replication seen in cancer and other human disorders. DNA replication initiates from DNA replication origins. In eukaryotes, replication is dependent on cell cycle kinases which function during S phase. Dbf4-dependent kinase (DDK) and cyclin-dependent kinase (CDK) act to phosphorylate the DNA helicase (composed of mini chromosome maintenance proteins: Mcm2-7) and firing facto... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.12688/wellcomeopenres.13884.1

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
ORCID:
0000-0003-2925-981X
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Oxford college:
Brasenose College
ORCID:
0000-0003-2001-076X
More from this funder
Funding agency for:
Nieduszynski, CA
Publisher:
F1000Research Publisher's website
Journal:
Wellcome Open Research Journal website
Volume:
3
Pages:
Article: 23
Publication date:
2018-03-06
Acceptance date:
2018-03-06
DOI:
ISSN:
2398-502X
Pubs id:
pubs:847397
URN:
uri:667ad7c1-148b-4f35-bae9-a9e0503d75c8
UUID:
uuid:667ad7c1-148b-4f35-bae9-a9e0503d75c8
Local pid:
pubs:847397
Language:
English
Keywords:

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