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FOXP1 suppresses immune response signatures and MHC class II expression in activated B-cell-like diffuse large B-cell lymphomas

Abstract:

The FOXP1 (forkhead box P1) transcription factor is a marker of poor prognosis in diffuse large B-cell lymphoma (DLBCL). Here microarray analysis of FOXP1-silenced DLBCL cell lines identified differential regulation of immune response signatures and major histocompatibility complex class II (MHC II) genes as some of the most significant differences between germinal center B-cell (GCB)-like DLBCL with full-length FOXP1 protein expression versus activated B-cell (ABC)-like DLBCL expressing pred...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/leu.2015.299

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Publisher:
Nature Publishing Group Publisher's website
Journal:
Leukemia Journal website
Volume:
30
Issue:
3
Pages:
605-616
Publication date:
2015-11-17
Acceptance date:
2015-10-13
DOI:
EISSN:
1476-5551
ISSN:
0887-6924
URN:
uuid:6675a9b8-c998-474a-8a10-74e2a31c2adc
Source identifiers:
587283
Local pid:
pubs:587283
Paper number:
3
Language:
English
Keywords:

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