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Journal article

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.

Abstract:

Fundamental to cell adhesion and migration, integrins are large heterodimeric membrane proteins that uniquely mediate inside-out signal transduction, whereby adhesion to the extracellular matrix is activated from within the cell by direct binding of talin to the cytoplasmic tail of the beta integrin subunit. Here, we report the first structure of talin bound to an authentic full-length beta integrin tail. Using biophysical and whole cell measurements, we show that a specific ionic interaction...

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Publication status:
Published

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Publisher copy:
10.1038/emboj.2009.287

Authors


Anthis, NJ More by this author
Wegener, KL More by this author
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Journal:
The EMBO journal
Volume:
28
Issue:
22
Pages:
3623-3632
Publication date:
2009-11-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:6670ea5d-0b43-4073-bddc-be8e2f437b80
Source identifiers:
196803
Local pid:
pubs:196803

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