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Identification of regulatory variants associated with genetic susceptibility to meningococcal disease

Abstract:

Non-coding genetic variants play an important role in driving susceptibility to complex diseases but their characterization remains challenging. Here, we employed a novel approach to interrogate the genetic risk of such polymorphisms in a more systematic way by targeting specific regulatory regions relevant for the phenotype studied. We applied this method to meningococcal disease susceptibility, using the DNA binding pattern of RELA - a NF-kB subunit, master regulator of the response to infe...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41598-019-43292-6

Authors


Borghini, L More by this author
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ORCID:
0000-0001-5586-6395
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ORCID:
0000-0001-7826-1516
Pinnock, E More by this author
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Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
9
Issue:
1
Pages:
Article: 6966
Publication date:
2019-05-06
Acceptance date:
2019-04-17
DOI:
ISSN:
2045-2322
Pubs id:
pubs:997120
URN:
uri:6661c439-8aaf-4468-8c39-0e7bf898f202
UUID:
uuid:6661c439-8aaf-4468-8c39-0e7bf898f202
Local pid:
pubs:997120
Language:
English
Keywords:

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