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Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion.

Abstract:

Naturally acquired immunity to malaria develops slowly, requiring several years of repeated exposure to be effective. The cellular and molecular factors underlying this observation are only partially understood. Recent studies suggest that chronic Plasmodium falciparum exposure may induce functional exhaustion of lymphocytes, potentially impeding optimal control of infection. However, it remains unclear whether the "atypical" memory B cells (MBCs) and "exhausted" CD4 T cells described in huma...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1202438

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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
190
Issue:
3
Pages:
1038-1047
Publication date:
2013-02-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:66524e54-ab5f-4d62-b269-4f7178cf031b
Source identifiers:
369849
Local pid:
pubs:369849

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