Journal article
α-Alkylation of ketimines using visible light photoredox catalysis
- Abstract:
- A novel α-alkylation of N-diphenylphosphinoyl ketimines with α-bromocarbonyl compounds has been accomplished using visible light photoredox catalysis. The reaction proceeds under remarkably mild conditions: at 35 °C, in 20 hours, under blue light irradiation (1 W), in the presence of a tertiary amine and catalytic amounts of Ru- and Ni-based complexes. Chemoselective transformation of the products provides access to 1,4-dicarbonyl compounds, protected GABA analogues and γ-lactams.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 664.1KB, Terms of use)
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- Publisher copy:
- 10.1039/C7RA09248B
Authors
+ European Research Council
More from this funder
- Grant:
- FP7/2007–2013, REA grant agreement no. 316955
- Publisher:
- Royal Society of Chemistry
- Journal:
- RSC Advances More from this journal
- Volume:
- 7
- Issue:
- 69
- Pages:
- 43655-43659
- Publication date:
- 2017-09-11
- Acceptance date:
- 2017-08-22
- DOI:
- EISSN:
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2046-2069
- ISSN:
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2046-2069
- Keywords:
- Pubs id:
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pubs:730963
- UUID:
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uuid:6651190a-04e0-4f9c-9a96-68f8f132cfc1
- Local pid:
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pubs:730963
- Source identifiers:
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730963
- Deposit date:
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2017-11-05
Terms of use
- Copyright holder:
- Franchino, Rinaldi, and Dixon
- Copyright date:
- 2017
- Notes:
- © the Author(s). This journal is © The Royal Society of Chemistry 2017. his article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
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