Proliferation and differentiation of human tenocytes in response to platelet rich plasma: an in vitro and in vivo study.

Journal article

Platelet rich plasma (PRP) is the autologous plasma fraction with a platelet-rich cellular component which is enriched with a number of growth factors. Due to its availability and low cost, PRP has become an increasingly popular clinical tool as an alternative source of growth factors for various applications, for example, tendon regeneration but with limited success in clinical trials. The main objective of the current study was to determine whether activated PRP [i.e., platelet rich plasma-...

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Authors: Wang, X; Qiu, Y; Triffitt, J; Carr, A; Xia, Z

• Journal: J Orthop Res
• Volume: 30
• Issue: 6
• Pages: 982-990
• Place of publication: United States
• Publication date: 2012-06-01
• DOI: 10.1002/jor.22016
• EISSN: 1554-527X
• ISSN: 0736-0266
• Language: English
• Keywords: Culture Media; Wound Healing; Decorin; Middle Aged; Cell Differentiation; Diffusion Chambers, Culture; Platelet-Rich Plasma; Male; Basic Helix-Loop-Helix Transcription Factors; Cells, Cultured; Cell Proliferation; Cattle; Gene Expression; Humans; Animals; Adult; Female; Collagen Type I; Tendons; Clot Retraction; Fetal Blood